Christina Applegate: A Beacon of Strength and Awareness for MS

11 mins read
Christina Applegate

Picture this: it was a crisp November day in Hollywood, filled with excitement and joy. Our beloved star, Christina Applegate, stepped into the spotlight, quite literally, as she received her very own star on the renowned Hollywood Walk of Fame. The cheers and applause echoed around, celebrating not only this achievement but also the release of the much-anticipated third and final season of her hit TV series, “Dead to Me,” now streaming on Netflix. What a moment of triumph!

Christina Applegate

For Christina, this occasion was a brave step into the public eye after a significant personal revelation. Just a few months prior, in August 2021, the star from the iconic “Married… With Children” shared her diagnosis of multiple sclerosis (MS). This event marked her first public appearance since that courageous disclosure.

As she prepared for the ceremony, Christina shared her feelings in an interview with The New York Times, saying, “This is the first time anyone’s going to see me the way I am. I put on 40 pounds; I can’t walk without a cane. I want people to know that I am very aware of all of that.”

The news of her MS diagnosis came during the filming of the current season of “Dead to Me,” adding a layer of complexity to her journey. Despite the challenges, Christina took to Twitter to bravely share her experiences, stating, “It’s been a strange journey. But I have been so supported by people that I know who also have this condition. It’s been a tough road. But as we all know, the road keeps going. Unless some [expletive] blocks it.”

Christina Applegate’s MS Journey

When it comes to multiple sclerosis (MS), it’s like a complex tapestry of experiences—no two patients share the exact same journey. Patricia K. Coyle, MD, an expert in the field and director of the MS Comprehensive Care Center at Stony Brook University Neurosciences Institute, sums it up perfectly: “One of the distinct features of MS is that no two patients are alike, and it’s a highly variable disease. It ranges from extraordinarily mild to extraordinarily severe.”

Christina Applegate’s journey with MS showcases this variety in experiences. In January 2021, she noticed something was off. At first, the symptoms were subtle, something easy to dismiss, as she mentioned in an interview with Variety. But by the time she started filming “Dead to Me” in May, it was like a sudden storm. “It was as if I got hit by a truck and didn’t know what was going on,” she described. The production had to halt for nearly five months to allow her to undergo necessary treatment.

Returning to the set post-treatment, the changes were noticeable. Applegate, once a vibrant actor always on her feet, now relied on a wheelchair. Crew members had to lend a helping hand, quite literally, to ensure scenes were captured. In her candid interview with The New York Times, she revealed her realization that what she initially perceived as minor issues—like numbness, tingling sensations, and balance problems—were actually symptoms of MS.

Barbara S. Giesser, MD, FAAN, a seasoned neurologist specializing in MS at the Brain Health Center of the Pacific Neuroscience Institute, provided insight into Applegate’s case. Dr. Giesser noted that it’s quite possible Applegate had been grappling with these symptoms even before receiving a formal diagnosis. Typically, MS doesn’t result in significant disability early on, making Applegate’s journey, characterized by a swift progression of the disease, quite unique.

Take A Dig Weight Matters

In the realm of MS, weight gain is a common concern shared by many, including someone as notable as Christina Applegate. It’s a multifaceted issue influenced by various factors, shedding light on the complexities of managing this condition.

Dr. Patricia K. Coyle, a prominent figure in MS research and care, explains that weight gain among individuals with MS can be attributed to multiple sources. Certain medications prescribed for managing symptoms, like steroids and drugs such as pregabalin (Lyrica) and gabapentin (Neurontin) aimed at alleviating neuropathic pain, may lead to weight gain. Additionally, the burden of dealing with symptoms like fatigue, depression, anxiety, and impaired mobility can contribute to changes in weight.

However, Dr. Coyle emphasizes that the disease-modifying therapies designed to tackle the core of MS generally do not cause substantial weight gain. This distinction is crucial, underlining the complex interplay between medication, symptoms, and the overall health journey for those with MS.

Understanding these dynamics offers valuable insights into navigating the often intricate relationship between multiple sclerosis and body weight.

Christina Applegate

Keeping Everyone in the Loop

Ever since Christina Applegate bravely opened up about her battle with MS, she’s been letting us into her world through social media. It’s like a window into her experiences and a way for her to connect with the public.

In October, she shared a photo on her social platforms, contemplating which stylish cane to use for an upcoming public event. It’s incredible how something like a cane can make a statement, right? When the big day of the Walk of Fame ceremony arrived, there she was, cane in hand, and choosing comfort over convention, she decided to go barefoot. In a tweet, she explained that wearing shoes can be uncomfortable and throws off balance for people grappling with MS. So, she took a bold step—literally—and embraced her true self that day, opting for comfort and authenticity.

It’s these little glimpses of her journey that help us understand the daily triumphs and challenges faced by individuals battling this condition. Sharing like this creates a sense of solidarity and a deeper connection with everyone who follows her story.

Sharing Hope and Knowledge: Applegate’s Advocacy for MS

Christina Applegate isn’t just fighting her battle with MS in silence; she’s using her platform to spread awareness and support. Recently, she encouraged her followers to watch a powerful documentary called “Introducing Selma Blair,” shedding light on actor Selma Blair’s life post her own MS diagnosis in 2018. Applegate believes in the strength of sharing experiences, acknowledging the reality of being technically disabled, and emphasizing how her life took a significant turn since the diagnosis.

In a tweet, she confessed, “Being technically disabled is what it is. I didn’t know what MS was before I had it. My life is changed forever. But my girl Selma Blair documented the first year. Which is hard.” It’s a glimpse into her honesty, vulnerability, and the immense strength she possesses in facing this challenging journey.

Dr. Coyle, a reputable expert in the field, appreciates Applegate’s public disclosure about her battle with MS. According to her, such openness is not just about sharing personal struggles; it’s about education. She highlighted that many people mistakenly confuse MS with muscular dystrophy and have little understanding of what MS truly entails. Dr. Coyle firmly believes that when prominent figures like Applegate step forward, well-informed about the disease, it has a profound impact. It brings a much-needed spotlight to MS, offering knowledge and hope to countless individuals who might be navigating this complex terrain silently.

Christina Applegate is not just an actress; she’s an advocate, spreading hope and knowledge, one powerful message at a time.


Christina Applegate, a public figure and MS warrior, is using her platform to raise awareness about multiple sclerosis (MS). She recommends the documentary ‘Introducing Selma Blair,’ which chronicles Selma Blair’s journey with MS, offering insights into the challenges of the first year after diagnosis. Applegate’s openness about her own experience serves as a beacon of strength and education, helping dispel misconceptions about MS and fostering a sense of community among those affected by the disease.